Genes and environment interact in a complex system that regulates energy balance, linked physiological processes, and weight. Excess adiposity typically evolves slowly over time, with a long-term positive energy balance. With weight gain overtime, excess lipids are distributed to many body compartments. When a negative energy balance is induced by reducing food intake, increasing activity levels, or both, thermodynamic prediction models accurately define the weight-loss trajectory in adherent patients.


Obesity is a complex disorder involving an excessive amount of body fat. Obesity isn’t just a cosmetic concern. It increases your risk of diseases and health problems, such as heart disease, diabetes and high blood pressure. Being extremely obese means you are especially likely to have health problems related to your weight. The good news is that even modest weight loss can improve or prevent the health problems associated with obesity. Dietary changes, increased physical activity and behavior changes can help you lose weight. Prescription medications and weight-loss surgery are additional options for treating obesity.