Genes and environment interact in a complex system that regulates energy balance, linked physiological processes, and weight. Excess adiposity typically evolves slowly over time, with a long-term positive energy balance. With weight gain overtime, excess lipids are distributed to many body compartments. When a negative energy balance is induced by reducing food intake, increasing activity levels, or both, thermodynamic prediction models accurately define the weight-loss trajectory in adherent patients.

在一个调节能量平衡、关联的生理过程和体重的复杂系统中,基因和环境相互作用。过度肥胖通常伴随时间缓慢发展,呈长期正能量平衡。随着时间推移体重增加,过多的脂质分布到许多身体隔室中。当减少食物摄入、增加活动水平或者两者同时进行,导致负能量平衡时,热动力学预测模型准确定义了坚持减重患者中的减重轨迹。

Obesity is a complex disorder involving an excessive amount of body fat. Obesity isn’t just a cosmetic concern. It increases your risk of diseases and health problems, such as heart disease, diabetes and high blood pressure. Being extremely obese means you are especially likely to have health problems related to your weight. The good news is that even modest weight loss can improve or prevent the health problems associated with obesity. Dietary changes, increased physical activity and behavior changes can help you lose weight. Prescription medications and weight-loss surgery are additional options for treating obesity.